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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG1 All Species: 19.39
Human Site: Y518 Identified Species: 38.79
UniProt: P19174 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19174 NP_002651.2 1290 148532 Y518 V L T S S K I Y Y S E E T S S
Chimpanzee Pan troglodytes XP_514650 1630 185027 Y858 V L T S S K I Y Y S E E T S S
Rhesus Macaque Macaca mulatta XP_001087295 1291 148567 Y518 V L T S S K I Y Y S E E T S S
Dog Lupus familis XP_542998 1249 143812 K496 N E D E E E P K E A S G S T E
Cat Felis silvestris
Mouse Mus musculus Q62077 1302 149650 Y518 V L T S S K I Y Y S E E T S S
Rat Rattus norvegicus P10686 1290 148530 Y518 V L T S S K I Y Y S E E T S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q2VRL0 637 72514
Frog Xenopus laevis Q32NH8 758 87399 S64 T K S T F S I S D I E T V R E
Zebra Danio Brachydanio rerio A5D6R3 784 89362 E90 Q Q T F S V T E V E C V R E G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13217 1095 124845 C401 C I Q A I A D C A F V S S E Y
Honey Bee Apis mellifera XP_624101 1134 132613 F440 V L T Q Q K L F Y T D T F S R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 A246 D Y S L S F W A M G K V N H C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 99.5 93.2 N.A. 95.3 96.9 N.A. N.A. 21.4 21.7 21.8 N.A. 21.4 45.1 N.A. 35.1
Protein Similarity: 100 79 99.7 94.5 N.A. 96.7 98.2 N.A. N.A. 32.4 37.3 36.3 N.A. 40 62 N.A. 50
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. N.A. 0 13.3 13.3 N.A. 0 40 N.A. 6.6
P-Site Similarity: 100 100 100 26.6 N.A. 100 100 N.A. N.A. 0 26.6 13.3 N.A. 20 66.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 9 0 9 9 9 0 0 0 0 0 % A
% Cys: 9 0 0 0 0 0 0 9 0 0 9 0 0 0 9 % C
% Asp: 9 0 9 0 0 0 9 0 9 0 9 0 0 0 0 % D
% Glu: 0 9 0 9 9 9 0 9 9 9 50 42 0 17 17 % E
% Phe: 0 0 0 9 9 9 0 9 0 9 0 0 9 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 9 0 9 0 0 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 9 0 0 9 0 50 0 0 9 0 0 0 0 0 % I
% Lys: 0 9 0 0 0 50 0 9 0 0 9 0 0 0 0 % K
% Leu: 0 50 0 9 0 0 9 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % N
% Pro: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % P
% Gln: 9 9 9 9 9 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 9 9 9 % R
% Ser: 0 0 17 42 59 9 0 9 0 42 9 9 17 50 42 % S
% Thr: 9 0 59 9 0 0 9 0 0 9 0 17 42 9 0 % T
% Val: 50 0 0 0 0 9 0 0 9 0 9 17 9 0 0 % V
% Trp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 42 50 0 0 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _